Search results for "Molecular spring"
showing 2 items of 2 documents
Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes
2019
Background: Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been linked to striated muscle disease. The pathways that govern titin-dependent cardiac growth and contribute to disease are diverse and difficult to dissect. Methods: To study titin deficiency versus dysfunction, the authors generated and compared striated muscle specific knockouts (KOs) with progressive postnatal loss of the complete titin protein by removing exon 2 (E2-KO) or an M-band truncation that eliminates proper sarcomeric integration, but retains all other functional domains (M-band exon 1/2 [M1/2]-KO). The authors evaluated c…
Towards Multifunctional Materials Incorporating Elastomers and Reversible Redox-Active Fragments
2014
This paper presents a novel and unique feature of metallacarboranes, consisting of the linkage of this redox electro-active site to a stretchable polymer. This is based on polyTHF, a known and applied material. This hybrid material has the two ends functionalized: one with the aforemen- tioned redox molecule and the other with a terminal OH group, both linked by a molecular spring. Moreover, the redox electro-active molecules can be synthesized with either cobalt (cobaltabisdicarbollide) or with iron (ferrabisdi- carbollide), species whose respective E1/2 value differs by almost 1 V. The polymerization mechanism, based on an in- termediate molecular crystal structure, is explained through a…